This domain spent twelve years serving a consortium that tried to answer one question — how do we coordinate the hunt for an HIV vaccine? — and then spent nine more years silent. Today it reopens as a public ledger of that hunt: every efficacy trial ever run, every outcome, every source, in one readable place.
Why "another" HIV information site
Because the existing answers to "why is there still no HIV vaccine?" are either too thin (a paragraph in a FAQ), too thick (40-page pipeline reports), or too optimistic (recruitment pages for trials that no longer exist). Nobody shows the whole ledger: nine efficacy programs that failed, one flicker at 31.2%, a prevention line that quietly won while the world waited, and a first-principles rebuild now in Phase 1.
"We hope to have such a vaccine ready for testing in approximately two years." MARGARET HECKLER, APRIL 23, 1984 — FORTY-TWO YEARS AGO THIS MONTH
What this site refuses to be
Not a news feed — the record moves slowly here, and we update when the record moves. Not an advocacy page — hope is not a substitute for a correlate of protection. Not a medical service — the prevention page tells you what exists; your clinician tells you what's right for you. And not, to be explicit, the old PAVE consortium: that organization is gone, and we claim nothing from it but the duty to keep its records findable.
How every number is kept
Each trial entry carries its registry number (NCT) and, where published, its journal citation. Claims are graded A/B/C at the evidence page. When we interpret rather than report — as in the funding-cycle analysis on why it's so hard — the passage says so. Corrections are welcome at contact@hivpave.org and are logged, not quietly patched.
What's next
The archive is live: nine trials and two active programs, the parallel ledger, a plain-language glossary. We'll publish when there's record to publish — a Phase 1 readout, a new efficacy filing, an approval on the prevention line. The chronicle keeps the score. That's the whole job.